It takes one click to wake up, and another click of the Select (top) button to actuate a device within a few seconds. The Select button has a very firm tactile switch so it would be very hard to do that accidentally.
The Mode (side) button cannot activate any devices unless you have a long press (four second hold) Quick Control set up on it. We recommend only assigning non-vital devices to this Quick Control feature if you're concerned it could get activated in your pocket or purse.